If you are going on a mixed bag safari , then the .375 H&H Magnum is the more sensible choice . If you are going on a safari specifically for Cape buffalo , then it would be thrilling to use a .416 Rigby . That is , if you can comfortably handle the recoil . Of course , ( in the context of a client hunter ) a .375 H&H Magnum is a perfectly acceptable tool for use against Cape buffalo . Just use a good quality soft nosed bullet . If you hand load , then I will strongly recommend South African 300 grain Rhino Solid Shanks . Should you wish to limit yourself to factory loads , then I would highly recommend Federal’s 300 grain Trophy Bonded Bear Claw .
Now , it IS possible to even use a .416 Rigby for a mixed bag safari if you really put your mind to it . Provided that you use the appropriate ammunition , of course . I routinely hunt game even as small as barking deer , with my .458 WM ( Winchester Magnum ) and ( by using solids ) excessive meat damage is kept to a minimum .