For my first trip to Africa I took only a custom M70 Super Grade 375 H&H loaded with 75 gr of N150 and Nosler 260 Partitions for 2800 fps. Scope for this plains game trek was a Leupold 4.5-14x40 VX-3. I chose this set up because the 375 in a Win 70 seemed very romantic to me for my first African safari, with the 260's it shot plenty flat and I wanted to get the lay of the land before I started bringing multiple firearms to heavily regulated destinations.
It worked out perfectly on 11 trophy animals ranging in size from springbok to eland, plus one very unlucky jackal. Dropped a sable in his tracks at 300 and change.
My PH called the it the hammer of Thor, while one landowner commented that I was pretty good with my "canon." (He watched the shot on the sable.) Apparently they were used to Americans showing up with smaller calibers.
It's worth noting that the 260 Nosler offered complete penetration on everything broadside. I only managed to recover two, expanded in typical partition fashion, and those were from quartering on shots on the kudu and a black wildebeest.
I don't think I ever cranked the scope to 14, 8 to 10 was plenty even on the longer shots. However I found the lower setting little handicap on a successful snapshot at a 52 inch kudu under 20 yards. A 1-4x would have been a bit wanting for the open plains in my opinion, when one is looking for a few inches difference in horn in a herd added power is more than welcome.
I think I'll bolt the new 2-12 VX-6 on it before the next trip if I can get comfortable with the increased scope height due to the 30mm tube for quick shooting. I've been hunting with low mounted 1 inch scopes for so long that tends to be a problem. If that turns out to be the case to a 2.5-8 VX-3 could get the nod.
That been said I'm building a 280 Ackley for plains purposes going forward, I plan to put the 4.5-14 on it. I figure that and the 375 will be a perfect African battery for buff, lion and plains. Sound reasoning?