For North American large game such as deer, antelope, even elk, I prefer the 270 over the 308 or the 30-06, just because of its flat ballistics, and good sectional density for a given weight. I have never had a game animal walk away from a solid hit from a 270 and even in the case of a very poorly placed shot, it did the job anyway. It is just a great all rounder. I do however understand the issue with African plains game having different physiology with the vitals positioned more forward and lower between the front legs thus requiring a bullet that can smash thru bone and flesh to get to the vitals. So, bigger, heavier and better sectional density for deeper penetration is all more important than it might be on most NA large game. That is why my 270 stays home for this trip. Still, I am a firm believer that shot placement is far more important than the rifle or cartridge used as long as it meets the prerequisite of providing enough penetration for the job at hand. The old adage says, "Use enough gun". So true and if in doubt I say a little too much gun is better than a little too less gun, every time.