I took my .375 BECAUSE I wanted an eland and you never know when you'll have an unexpected chance at something big and dangerous. The problem with the .308 Win is the way it handles bullets of 180 and up. With 150s and 165s its the equal of the '06, but the difference in case capacity becomes an issue with 180s and 200s. Any 180 .308 factory stuff I've clocked has been anemic, say around 2400 to 2500 fps or so, not 300 yard fodder when given a choice. Good safe hand loads, stuff you'd want to count on half a world away, can boost this only to about 2600 or so.
Couple years back I shot a 6x6 bull elk with my favorite deer rifle, a Win 70 Featherweight, using 165 Hornady Superformance ammo clocked at 2800 fps. First shot was high lung as he was running at 19 paces, perfect mushroom under the far hide. Second shot was an "anchoring shot" at 100 as he was motivating over a small rise, struck the root of the tail. Bullet struck the spine and rolled him over the hill, dead when I arrived.
But when I saw what the 165 Spire Point did on that big bone, completely disintegrated down to the base, small pieces of lead and copper scattered about leaving just a small crack in the bone, I'll have no part of that bullet on big animals again. Would have done the same thing on the shoulder bone I imagine. Great reason to upgrade to a 30'06 or .300 with 180 gr. at 2800 fps + controlled expanding bullets if you ask me.
That been said, even though the 500 lb. bull was dead (from the lung shot), if I had to do it again I'd rather have a Barnes or a Partition in the pipe for the next one to cover more 'eventualities.' Same goes for Eland, wildebeest, sable or kudu at any range, and I'd prefer to keep the range a bit closer.