I took my Blaser R8 with a .300 WSM to SA a couple of months ago. I used Federal Fusion 180 grain factory bullets. All performed flawlessly. No bullet failures, no feed issues. I shot 4 springbuck from 160-260 yards, roan from 160 yds, waterbuck from 230 yrds, blue wildebeest from 250 ish, nyala, warthog, bushpig, and zebra. A pretty good mix of plains game large and small. With the exception of the nyala and zebra all were one shot kills. The warthog took 2 shots but I had a small window in some rocks to get an anchoring shot on him. The nyala and zebra were both moving as I shot so both were a bit low and back from my aimpoint. The .300 WSM does just fine on plains game. The smaller animals do have a big exit hole though. As with all calibers I think shot placement is far more important than grains, caliber bullet style etc. I was shooting clover leafs with my rifle before I went over and was very confident with it. Moving targets are whole other issue for me. Practice on and off sticks kneeling, sitting and standing. You will have some awkward positions to shoot from but practice will make you confident. Good luck and let us know how you do.