I’ve been successfully hunting most of my Cape buffalo with a .375 Holland & Holland Magnum, over the years.
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The most impressive bullet in a .375 Holland & Holland Magnum which I’ve ever used on Cape buffalo, is Federal’s 300Gr Trophy Bonded Bear Claw controlled expansion factory load. It’s more than capable of breaking a fully grown bull’s scapula and reaching the vitals from absolutely any angle. And I have (so far) enjoyed my greatest success against these gigantic African bovines with these excellent bullets.
However, Federal never seems to have ammunition loaded with Trophy Bonded Bear Claw or Sledgehammer bullets in stock these days (for the last few years, at least).
Another favorite bullet of mine in .375 caliber, is the 300Gr Rhino Solid Shank. For all points and purposes, this is a clone of Jack Carter’s Trophy Bonded Bear Claw design. Unfortunately, it’s only available as a hand loading component.
I’m yet to use Barnes TSX bullets on Cape buffalo. But I did successfully hunt my most recent hippopotamus bull on land on my latest African safari, with a 300Gr Barnes TSX factory load (a one shot affair). To say that I was immensely satisfied, would be the gross understatement of the year. I would definitely feel 100% confident in using this bullet on Cape buffalo in my future African safaris.