Double rifles are unique if not strange behaving contraptions.
I love them.
However, the only way to know how much changing ammunition specs will matter to accuracy / regulation, is to actually fire the rifle.
Without that, trying to predict how it will throw bullets from any ammunition, that is very much different than what one’s individual rifle is regulated for, is like trying to guess what the weather will be doing on one particular day, 10 years from now.
I once owned an Army & Navy double in .450 No2 Nitro.
It shot 480 gr Hornady DGX and DGS into very satisfying little groups, barrel to barrel.
Same powder charges, same primers, same brass but 480 gr Woodleighs and the groups would spread out a bit.
500 gr Hornady and Woodleigh either or both and the groups would likewise spread out more than I wanted.
I once owned a Merkel SxS in .375 H&H that didn’t regulate with the ammunition it supposedly was regulated for (Federal regular old formerly cheap 300 gr RNSP), and the right side barrel showed dangerous pressure signs, adding insult to injury.
So, I had it re-regulated to 300 gr round nose Hornady softs and solids @ 2400 fps and it was super accurate as doubles go.
However, it also regulated perfectly with Federal factory “Premium” ammunition they used to offer with 300 gr Nosler Partitions.
This, in spite of said NP ammo also showing dangerous pressure signs in my right side barrel, just like the ammunition it was supposed to be regulated with.
Except that the NP load was super accurate.
Go figure that one out, sheesh.