Double BC,
I'm but a simple client however, in Southern African countries, hunting season is if full swing so, maybe I can chime in until such time as the PHs get a free moment to comment.
The PH that I have hunted the most with (Hannes Swanepoel) primarily uses a Brno Mauser, model 600, .30-06 that, his father had given to him, when Hannes was a boy.
It is combined with a Zeiss Conquest 3 to 9x scope and 220 grain Hornady round nose softs, hand-loaded at 2400 feet per second.
He told me that when he was Game Warden in The Kruger Park, South Africa, he had shot very dead more than one or two problem (aggressive) lions with this combination.
He is an exceptional rifle shot and so, even larger animals such as eland, waterbok and zebra are generally one shot conclusions for him with his trusty .30-06 / 220 grainers.
When he shoots for the kitchen, this rifle is almost always what he uses.
He also has a Brno Model 602 magnum in .375 H&H, with the same scope on it, and 300 grain Hornady round nosers also at 2400 fps.
Hannes as well has as a custom built for him large bore repeater, (on a CZ Model 550 Magnum Mauser action), caliber .458 3inch Express which, he "only" loads to somewhere between 2150 to 2200 fps (to keep chamber pressure down in the hot African sun).
With 500 grain flat nose solids (Dzombo or Stewart brand?), it is his "stopping rifle", when backing clients on heavy dangerous game, (primarily elephant, buffalo and hippo these days).
I have hunted with his .30-06 and also have done some culling with it as well plus, I've hunted a little bit with his .375 and I would not hesitate to use either one again.
Both are absolute death rays, as far as my opinion goes.
As for the .458 3" Express, I've only fired it at a paper target, set in front of a termite mound and in spite of how wimpy my shoulder is, I found that cannon surprisingly controllable and also, satisfyingly quite accurate.
In fact, I liked it so much that, as soon as I could afford it, I had one just like it built to fit me.
Mine however is in caliber .458 Lott, as the Gunsmith already had a Lott chamber reamer and I was not sure I could find 3 inch brass just hanging from every tree anyway.
(I'm one of these weirdoes that goes hunting as an excuse to own decent rifles).
Well anyway, blah, blah, blah, out.
Velo Dog.