My personal favorites are my .300 Weatherby for plains game, and my .375 RUM for buffalo (based on my vast experience of one buffalo
).
I used a 7mm Rem mag on my first South African hunt and it easily made one shot kills on kudu, blue wildebeest, and gemsbok.
Because my second African hunt included buffalo, I built and took my .375 RUM and a 7mm RM. When I hunted my buffalo, my Zimbabwe PH was next to me with his .458 Win, but as far as I know, he never clicked the safety off. The PG that I shot on that hunt were all easily killed with whichever of these rifles that I shot them with.
My third South African hunt included Cape eland and kudu and my PH told me that I might have to take 200+ yard shots across heavily brushed canyons so my rifle on that hunt was my .375 RUM shooting 270 gr TSX handloads. That rifle and bullet combination worked great on all the animals that I shot with them, including a couple of 300+ yard shots. However I did borrow a .308 Win with FMJ bullets for my Cape grysbok hunt, because of the excessive pelt damage that my .375 RUM/270 gr TSX made on a couple of steenboks and a jackal.
The last hunt that I did in South Africa, I only took my .300 Weatherby with 168 gr TTSX handloads. It easily made one shot kills on all of the PG animals that I shot with it, including a couple that were at or over 300 yards. Because I had hoped to hunt a couple of small cats, I also developed a load with and took 150 gr FMJ bullets for them.