1). IF the .22lr has a good trigger and is reasonably accurate out to 50 yrds.
2). IF the .22lr is similar size to an average size hunting rifle ie: Not a 4.5 lb. Ruger 10/22.
Either way, as you point out, it’s certainly never bad to practice with a .22lr - won’t cause ‘flinch’ and helps you hold steady and learn trigger squeeze. My point is only that practicing with a larger size rifle in .22lr (Kimber Super America?) helps replicate many hunting rifles in size, weight, trigger quality and accuracy.
My theory is this: take Olympic shooter at range (and he will already have millions of 22lr rounds fired), give him a bit of training with 308 - 300 win mag - 375 HH - 416. And he will excel in it as soon as he gets the grip on rifle and recoil.
The key word is trigger time.
My own training, is like this:
Frequent competitions in 22 lr, 9x19, 38 spwc, 308 win, and recreational trap.
But specific training sessions are like this:
My next theory is better to shoot ten times, in ten days, 10 shots each day, rather then shoot 100 rounds in a day... That being said:
pistol training, up to month before competition:
The goal of training - maximize number of hits, in bulls eye.
25 rounds 22lr, then 25 rounds 9x19. keep the score, keep the record.
Repeat each day, up 3 to 5 times per week.
As competition day closes, I follow my recorded ups and downs in training score (training score is sinusoidal), and I try to predict upper curve in result for competition day.
For rifle, training for safari, is like this
my safari rifle is 375 H&H. The goal of training, keep all hits in vital zone, in field positions and from stick
2 boxes of 22lr - standing position free, or from stick, 50 meters. (100 rounds)
a box or more 308 win (20 rounds), same positions, or 30-06, depending which rifle I prefer for that particular day. FMJ, cheapest ammo. (I dont care for submoa myth)
5 to 10 rounds or few more 375, same positions.
Rifles: CZ 452, Tikka t3, sako 85, and zkk 602 in 375 - not really comparable in size, or ergonomics.
Frequency: Occasional visit to range, month or two before safari. 5 to 10 sessions. But keep in mind I shoot everything else in the mean time. So, generally I am warmed up. It is not a problem to keep hits at vital zone on animal size target.
Exceptions, decisions:
Besides personalized training as described above. I never shot a double rifle in my life.
And on my last safari (Zimbabwe, September 2025), I had option to hunt with double rifle in 416. (recoil unknown, handling unknown to me, rifle unknown to me, rental rifle)
I never shot a rifle or shotgun with two triggers either.
So, there was a challenge. New uncharted territory.
So, for "advanced" training for this occasion I borrowed double rifle 30-06 from a friend, and tried at range. My reloading was clumsy, not exactly how I imagined the reloading when facing charging animal in fury.
Then I tried from borrowed shotgun with two triggers, some trap shooting.
And general conclusion with those two guns was: two triggers are doable for me, but double rifle reloading in stressful situation is not for me.
Finally I hunted with bolt action, rental... It was like being at home.
Result, 6 one shot kills, and luckily all of them DRT, including one very large DG specimen, the rest plains game.
Where we now stand after all this being said?
In my perspective, the number of shots fired to get some muscle memory with 22lr is incomparable with number of shots fired with center fire rifle. On the end of the day, trigger time counts.
Now some observations: I am member of shooting club, and hunting club.
People whom I know, and who do not have and shoot 22 - generally shoot poor, I've seen that. They are "recreational shooters", not serious.
Ammunition of center fire rifle is too expensive, most of the hunters cannot afford ammo to punch the paper regularly. Many of them hunt from blind, on close range, 50 meters, from rest, maximum 100 meters.
There is very small percentage of good shots in hunting community that I have seen, but those are: people with high number of kills in their life (experience), they reload their ammunition, they test their ammunition (this is trigger time), and generally they know what they are doing, and they have enough experience not to shoot when they are not certain. But those are really small numbers that I know.