The condition of the brass, especially the case web and primer pocket, is going to depend on how “hot” (i.e. pressure) your reloads are. The case neck/shoulder area will become work hardened the more times you size the brass. You can alleviate work hardening by periodically annealing the neck/shoulder area. It’s not practical/feasible to correct primer pockets once they become oversized from multiple high pressure loads. I will anneal cases every 3-5 firings depending on the cartridge/load. If you maintain a reasonable pressure level (i.e. velocity window) on your handloads you should be able to load a piece of 375 Ruger brass (with periodic annealing) on an ongoing basis. It’s the primer pockets/case web that will typically kill a case.
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