I can speak to the .375 Ruger, I’ve had excellent performance on animals as small as bushbuck and warthog up to elephant and buffalo. The elephant was a collaboration to the brain so who knows how that went but one buffalo took the 300 grain DGX to the left shoulder and was recovered under the skin of the right shoulder. The bull almost went down on impact and he turned straight away, I then stuck a 300 grain DGS up the rear and it was recovered in the dewlap. Shot a couple of “meat“ buffalo but wasn’t around for the skinning so can’t speak to the performance except for dead buffalo.