The Dwarf Forest Buffalo in profile picture drop one shot, I but put a second one in him for insurance. We were in high grass, as can see in the picture and we got a head of herd (5-6) as they were feeding east to west. I climbed up on a termite mound and buddy in the pic, had to push against my back me so I would not fall. They slowly feed towards and about 10 yards or less (the grass was so thick I had to wait until they were right on top of us) I fired between his shoulders. From that elevation position maybe 5 feet up I felt like we were in the same room. He dropped and I fired another for insurance. The PH was watching the rest of the herd, as he worried they might charge and told me to stay focused on the downed bull. The PH was on the backside of the mound. The mound kinda parted the herd like Charleston Heston. I was using a 378 Weatherby, that belonged to the PH, because as the time hunters could not bring in their own firearms in the Congo. So, a evaluated position between the shoulder does the trick for a DRT.
Another time on my third CB, I was using a TC shooting 373 JDJ. The bachelor herd was just on the edge on some six feet+ tall saw grass, heads facing away from the grass and we were slightly elevated on a bank maybe two feet higher about 25 yards away. I shot him in the lower third of the shoulder in the heart, he turned and ran maybe 15-20 yards into the grass with the rest of the herd following, but they kept moving on. Don Price, our PH, said he is hit good just wants us to come in an get him. But we aren't falling for that trick. About the same time, literally all this as happened in less minute he started to bellow. We could hear him and just make out his black mass only so slightly from our elevation position. We could not tell what direction he standing, but figured his head was facing the way he just came from. So, Don told me fire a shot at my best guess location. Well, the bellowing stopped almost instantly, trick or not we waited a few minutes and went in. It was not until we moved the bull that we saw where my my second shot hit. Right in his ear hole.
So, as for shot placed, one shot and DRT, the ear hole with a 375 JDJ, 300gr solid will do the trip.