375 Ruger Wildcats

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@Saul
The 25-375 Ruger would be a real barrel burner plus you wouldn't get a a slow enough powder to get the best out of it.
The 257 Weatherby has a barrel life of around 1,500 rounds the 25 Ruger would be licky to get 6-800.
Bob

Yeap, in this case, you would be better off necking down the 6.5 PRC, because even using the 7 PRC would be detrimental to barrel life.