I loaded both the 250gr and 300gr and both shot very well in my 375 in preparation for my trip to Namibia. I took both loads and due to stupidity and bad handling on my part, I got them mixed up once I got there. I shot two kudu bulls, a gemsbok, a steinbok, a zebra stallion, a blesbok, and an impala with them. All shots were pass throughs except the gemsbok and the bullet deflected off the far shoulder and lodged in the backbone. As expected, it retained nearly all of its weight. All but one kudu dropped within a few steps. I have nothing but respect for Barnes and will continue to use only Barnes for my hunting loads. I don't recall the load I used at the moment, but it is a very basic one where I don't care about the fps too much. I practiced at 200yds leading up to the trip but all but one shot was 150yds or less, most were much less due to the great work of my PH, Pieter Grobbelaar. The farthest was around 250yds on the kudu bull that ran a bit, but it was the guy behind the scope and not the bullet. This bull turned to run at the instant I shot and the angle changed, but he was recovered about 200yds later, but the bullet did its job very well making the tracking extremely easy. My belief is that if one performs better for you, stick with it. If they both work, all the more better. If you can't get your hands on the 250's, then you may have a different decision to make. For some additional info, I shoot a Remington 700 off the shelf rifle that I have had a muzzle break added to by my friends at MG Arms, Inc., so my rifle is a bland one but liked the Barnes. Best of luck to you in your trials and great luck in Africa! Shoot as many trophies as you can afford, you'll be very glad you did!!!!