I have used the 250gr version of the North Fork bonded cores on PG in South Africa. They work great. My hunt last year, I only took my 375HH and these rounds. I will never forget the scene on a Blue Wildebeest, it was like from a horror movie with all the blood.
I also took a Sable on that hunt. One shot broadside right on the shoulder, heart shot for sure. Sable ran around in a circle, dying close to where he was standing when shot.
So all things considered, I'd hunt yet again with the 250's. However, my friend
@AZ KJ was on the same trip. Long story short, I had loaded 300gr North Forks for him prior to his moving to Texas a few months before our trip.
After all was said and done, I have decided to defer to the wisdom of
@Red Leg and to keep things simple in the future. As long as North Fork (who is coming back into business now) or Swift make their 300gr bonded bullets, that will be the load and only load for my 375HH. There is much to be said for keeping things simple.
The 300gr load will run at 2550fps and will still hit hard at 300 yards on the rare occasion you need to shoot that far in Africa. Just something to consider as an alternative, but you'll be fine either way.